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Version: 16.11d (Release date: 2016-11-28)
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Therapeutic Epinephrine (Code C473)

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Terms & Properties

Preferred Name: Therapeutic Epinephrine

Definition: The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation.

Display Name: Therapeutic Epinephrine

Label: Therapeutic Epinephrine

NCI Thesaurus Code: C473 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0014563  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adrenal
Adrenaline
adrenaline
Epi
EPINEPHRINE
Epinephrine
Therapeutic Epinephrine

External Source Codes: 
CAS Registry Number 51-43-4 (see NLM ChemIDplus info)
FDA UNII Code YKH834O4BH
ChEBI ID CHEBI:28918 (see ChEBI info)
NSC Code 62786 (see NCI DTP info)
PDQ Closed Trial Search ID 41857
PDQ Open Trial Search ID 41857 (check for NCI PDQ open clinical trial info)
UMLS CUI C0014563

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C9H13NO3
code C473
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Epinephrine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C473

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