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Version: 16.11d (Release date: 2016-11-28)
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Enalapril Maleate (Code C468)

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Terms & Properties

Preferred Name: Enalapril Maleate

Definition: The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Display Name: Enalapril Maleate

Label: Enalapril Maleate

NCI Thesaurus Code: C468 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0600128  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Enacard
Enalapril Maleate
ENALAPRIL MALEATE
Renitec
Vasotec

External Source Codes: 
CAS Registry Number 76095-16-4 (see NLM ChemIDplus info)
FDA UNII Code 9O25354EPJ
ChEBI ID CHEBI:4785 (see ChEBI info)
PDQ Closed Trial Search ID 42544
PDQ Open Trial Search ID 42544 (check for NCI PDQ open clinical trial info)
UMLS CUI C0600128

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C20H28N2O5.C4H4O4
code C468
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Enalapril
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C468

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