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Version: 17.06d (Release date: 2017-06-26)
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Echinomycin (Code C462)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Echinomycin

Definition: A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis. (NCI04)

Label: Echinomycin

NCI Thesaurus Code: C462 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0013508  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bis-Quinoline Analogue
BRN 0078671
Echinomycin
Echinomycin A
Levomycin
N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide)
Quinomycin A
SK 302B

External Source Codes: 
CAS Registry Number 512-64-1 (see NLM ChemIDplus info)
NSC Code 526417 (see NCI DTP info)
PDQ Closed Trial Search ID 39587
PDQ Open Trial Search ID 39587 (check for NCI PDQ open clinical trial info)
UMLS CUI C0013508

Other Properties:
     Name Value (qualifiers indented underneath)
code C462
Legacy_Concept_Name Echinomycin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C462

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