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Version: 17.06d (Release date: 2017-06-26)
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Promethazine Hydrochloride (Code C45907)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Promethazine Hydrochloride

Definition: The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone.

Label: Promethazine Hydrochloride

NCI Thesaurus Code: C45907 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0546876  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anergan
N-(2-Dimethylaminopropyl-1)phenothiazine Hydrochloride
Phencen
Phenergan
Prometh
Promethazine HCl
Promethazine Hydrochloride
PROMETHAZINE HYDROCHLORIDE
Prorex
Provigan
Remsed
V-Gan
Zipan-50

External Source Codes: 
CAS Registry Number 58-33-3 (see NLM ChemIDplus info)
FDA UNII Code R61ZEH7I1I
ChEBI ID CHEBI:8462 (see ChEBI info)
NSC Code 231688 (see NCI DTP info)
PDQ Closed Trial Search ID 39567
PDQ Open Trial Search ID 39567 (check for NCI PDQ open clinical trial info)
UMLS CUI C0546876

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H20N2S.HCl
code C45907
Contributing_Source FDA
Legacy_Concept_Name Promethazine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C45907

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