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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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EF5 (Code C45873)

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Terms & Properties

Preferred Name: EF5

Definition: A fluorinated derivative of the 2-nitroimidazole etanidazole. EF5 is effective in accessing oxygen levels in tumor tissue through its adduct formation to intracellular macromolecules in the absence of oxygen. Reduction of this agent is carried out by a diverse group of enzymes in the cytoplasm, microsomes and mitochondria. Tissue hypoxia detection via EF5 has been reported in several cancers, including squamous cell carcinoma of the cervix and the head and neck, and in sarcoma.

NCI-GLOSS Definition: A drug that is used to plan cancer treatment by measuring oxygen levels in tumor cells.

Display Name: EF5

Label: EF5

NCI Thesaurus Code: C45873 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0382334  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) Acetamide

External Source Codes: 
CAS Registry Number 152721-37-4 (see NLM ChemIDplus info)
FDA UNII Code 383HJ2T87O
NSC Code 684681 (see NCI DTP info)
PDQ Closed Trial Search ID 43025
PDQ Open Trial Search ID 43025 (check for NCI PDQ open clinical trial info)
UMLS CUI C0382334

Other Properties:
     Name Value (qualifiers indented underneath)
code C45873
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EF5
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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