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Version: 16.10e (Release date: 2016-10-31)
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Droperidol (Code C458)

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Terms & Properties

Preferred Name: Droperidol

Definition: A butyrophenone with anti-emetic, sedative and anti-anxiety properties. Although the exact mechanism through which droperidol exerts its effects is unknown, droperidol may block dopamine receptors in the chemoreceptor trigger zone (CTZ), which may lead to its anti-emetic effect. This agent may also bind to postsynaptic gamma-aminobutyric acid (GABA) receptors in the central nervous system (CNS), which increases the inhibitory effect of GABA and leads to sedative and anti-anxiety activities.

NCI-GLOSS Definition: A drug used to prevent nausea and vomiting in patients who receive anesthesia before surgery. It is also used to treat anxiety. Droperidol is a type of antiemetic, adjunct anesthesia, and antipsychotic.

Label: Droperidol

NCI Thesaurus Code: C458 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0013136  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DROPERIDOL
Droperidol
droperidol
Inapsine

External Source Codes: 
CAS Registry Number 548-73-2 (see NLM ChemIDplus info)
FDA UNII Code O9U0F09D5X
ChEBI ID CHEBI:4717 (see ChEBI info)
NSC Code 169874 (see NCI DTP info)
PDQ Closed Trial Search ID 39227
PDQ Open Trial Search ID 39227 (check for NCI PDQ open clinical trial info)
UMLS CUI C0013136

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H22FN3O2
code C458
Contributing_Source FDA
Legacy_Concept_Name Droperidol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C458

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