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Version: 17.06d (Release date: 2017-06-26)
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Doxycycline (Code C457)

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Terms & Properties

Preferred Name: Doxycycline

Definition: A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.

NCI-GLOSS Definition: A drug used to treat many types of bacterial infections. It stops the growth of bacteria by keeping them from making proteins. It is a type of antibiotic.

Display Name: Doxycycline

Label: Doxycycline

NCI Thesaurus Code: C457 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0013090  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Doxycycline
DOXYCYCLINE
doxycycline
Doxycycline Monohydrate

External Source Codes: 
CAS Registry Number 17086-28-1 (see NLM ChemIDplus info)
FDA UNII Code N12000U13O
ChEBI ID CHEBI:60648 (see ChEBI info)
PDQ Closed Trial Search ID 42494
PDQ Open Trial Search ID 42494 (check for NCI PDQ open clinical trial info)
UMLS CUI C0013090

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H24N2O8.H2O
code C457
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Doxycycline
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C457

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