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Version: 17.08d (Release date: 2017-08-28)
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Recombinant Human Endostatin (Code C45515)

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Terms & Properties

Preferred Name: Recombinant Human Endostatin

Definition: A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Endostatin is made from a type of collagen (a protein found in cartilage and other connective tissue). It may prevent the growth of new blood vessels that tumors need to grow. Endostatin is a type of antiangiogenesis agent.

Label: Recombinant Human Endostatin

NCI Thesaurus Code: C45515 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1705207  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Endostatin
Recombinant Human Endostatin

External Source Codes: 
PDQ Closed Trial Search ID 459758
PDQ Open Trial Search ID 459758 (check for NCI PDQ open clinical trial info)
UMLS CUI C1705207

Other Properties:
     Name Value (qualifiers indented underneath)
code C45515
Legacy_Concept_Name Recombinant_Endostatin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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