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Version: 16.11d (Release date: 2016-11-28)
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Disulfiram (Code C447)

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Terms & Properties

Preferred Name: Disulfiram

Definition: A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid. This leads to an accumulation of acetaldehyde that produces a variety of very unpleasant symptoms referred to as the disulfiram-alcohol reaction. This reaction includes, but is not limited to, flushing, headache, respiratory difficulty, nausea,vomiting, sweating, thirst, chest pain, tachycardia, blurred vision and hypotension.

NCI-GLOSS Definition: A drug that slows the metabolism of retinoids, allowing them to act over a longer period of time.

Display Name: Disulfiram

Label: Disulfiram

NCI Thesaurus Code: C447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012772  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antabuse
Bis(diethylthiocarbamoyl) Disulfide
Disulfiram
DISULFIRAM
disulfiram
DS
Tetraethylthioperoxydicarbonic Diamide
Tetraethylthiuram Disulfide
Teturamin
TTD

External Source Codes: 
CAS Registry Number 97-77-8 (see NLM ChemIDplus info)
FDA UNII Code TR3MLJ1UAI
ChEBI ID CHEBI:4659 (see ChEBI info)
NSC Code 25953 (see NCI DTP info)
PDQ Closed Trial Search ID 42291
PDQ Open Trial Search ID 42291 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012772

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C10H20N2S4
code C447
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Disulfiram
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C447

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