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Version: 17.06d (Release date: 2017-06-26)
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Disulfiram (Code C447)

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Terms & Properties

Preferred Name: Disulfiram

Definition: An orally bioavailable carbamoyl derivative and a proteasome inhibitor that is used in the treatment of alcoholism, with potential antineoplastic and chemosensitizing activities. Disulfiram (DSF) may help to treat alcoholism by irreversibly binding to and inhibiting acetaldehyde dehydrogenase, an enzyme that oxidizes the ethanol metabolite acetaldehyde into acetic acid. Inhibition of acetaldehyde dehydrogenase leads to an accumulation of acetaldehyde and produces a variety of very unpleasant symptoms, which together are referred to as the disulfiram-ethanol reaction (DER). In addition, DSF has a strong ability to chelate metals and its antineoplastic activity is highly dependent upon binding to copper (Cu), a metal that selectively accumulates in cancer cells. DSF/Cu generates reactive oxygen species (ROS) and inhibits proteasome activity, leading to an accumulation of ubiquitinated proteins; both of these processes result in induction of apoptosis. Also, DSF/Cu inhibits various cancer-specific pathways, which leads to inhibition of tumor cell growth.

NCI-GLOSS Definition: A drug that slows the metabolism of retinoids, allowing them to act over a longer period of time.

Display Name: Disulfiram

Label: Disulfiram

NCI Thesaurus Code: C447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012772  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antabuse
Bis(diethylthiocarbamoyl) Disulfide
Disulfiram
disulfiram
DISULFIRAM
DS
Tetraethylthioperoxydicarbonic Diamide
Tetraethylthiuram Disulfide
Teturamin
TTD

External Source Codes: 
CAS Registry Number 97-77-8 (see NLM ChemIDplus info)
FDA UNII Code TR3MLJ1UAI
ChEBI ID CHEBI:4659 (see ChEBI info)
NSC Code 25953 (see NCI DTP info)
PDQ Closed Trial Search ID 42291
PDQ Open Trial Search ID 42291 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012772

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H20N2S4
code C447
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Disulfiram
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C447

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