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Version: 17.06d (Release date: 2017-06-26)
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Phenoxybenzamine Hydrochloride (Code C44435)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Phenoxybenzamine Hydrochloride

Definition: The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.

Label: Phenoxybenzamine Hydrochloride

NCI Thesaurus Code: C44435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0242430  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dibenzyline
N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride
Phenoxybenzamine Hydrochloride
PHENOXYBENZAMINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 63-92-3 (see NLM ChemIDplus info)
FDA UNII Code X1IEG24OHL
NSC Code 37448 (see NCI DTP info)
UMLS CUI C0242430

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H22ClNO.HCl
code C44435
Contributing_Source FDA
Legacy_Concept_Name Phenoxybenzamine
Semantic_Type Hazardous or Poisonous Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C44435

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