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Version: 16.11d (Release date: 2016-11-28)
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Iron Dextran Complex (Code C44394)

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Terms & Properties

Preferred Name: Iron Dextran Complex

Definition: A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation.

Label: Iron Dextran Complex

NCI Thesaurus Code: C44394 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0022092  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dexferrum
Imferon
INFeD
Iron Dextran Complex
Iron Dextran Injection

External Source Codes: 
CAS Registry Number 9004-66-4 (see NLM ChemIDplus info)
NSC Code 57682 (see NCI DTP info)
PDQ Closed Trial Search ID 551718
PDQ Open Trial Search ID 551718 (check for NCI PDQ open clinical trial info)
UMLS CUI C0022092

Other Properties:
Name Value (qualifiers indented underneath)
code C44394
Legacy_Concept_Name Iron_Dextran_Complex
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C44394

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