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Version: 17.06d (Release date: 2017-06-26)
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Hydromorphone Hydrochloride (Code C436)

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Terms & Properties

Preferred Name: Hydromorphone Hydrochloride

Definition: The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.

Label: Hydromorphone Hydrochloride

NCI Thesaurus Code: C436 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700533  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dilaudid
Dilaudid HP
Dimorphone
Exalgo
Hydromorphone Hydrochloride
HYDROMORPHONE HYDROCHLORIDE
Hydrostat
Hymorphan
Laudicon
Novolauden

External Source Codes: 
CAS Registry Number 71-68-1 (see NLM ChemIDplus info)
FDA UNII Code L960UP2KRW
ChEBI ID CHEBI:5791 (see ChEBI info)
NSC Code 19046 (see NCI DTP info)
PDQ Closed Trial Search ID 574280
PDQ Open Trial Search ID 574280 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700533

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For pain in opioid-tolerant patients.
Chemical_Formula C17H19NO3.HCl
code C436
Contributing_Source FDA
Legacy_Concept_Name Hydromorphone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C436

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