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Version: 17.06d (Release date: 2017-06-26)
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Diethylstilbestrol (Code C433)

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Terms & Properties

Preferred Name: Diethylstilbestrol

Definition: A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.

NCI-GLOSS Definition: A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth.

Label: Diethylstilbestrol

NCI Thesaurus Code: C433 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012203  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
.alpha., .alpha.'-Diethylstilbenediol
3,4-Bis(p-hydroxyphenyl)-3-hexene
3, 4-Bis(p-hydroxyphenyl)-3-hexene
3-Hexene,3,4-bis(p-hydroxyphenyl)-
4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene
4,4'-Dihydroxy-alpha,beta-diethylstilbene
Acnestrol
Alpha,alpha'-diethylstilbenediol
Antigestil
Apstil
Boestrol
Bufon
Cyren A
DES
Diastyl
Diethylstilbenediol
Diethylstilbestrol
DIETHYLSTILBESTROL
diethylstilbestrol
Diethylstilbestrolum
Diethylstilboestrol
Distilbene
Domestrol
Estrobene
Estromenin
Estrosyn
Fonatol
Grafestrol
Makarol
Microest
Milestrol
Neo-Oestronol I
Oestrogenine
Oestromenin
Oestromensyl
Oestromon
Palestrol
Serral
Sexocretin
Sibol
Stilbestrol
Stilbetin
Stilboefral
Stilboestroform
Stilboestrol
Stilkap
Synestrin
Synthoestrin
Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3
Vagestrol

External Source Codes: 
CAS Registry Number 56-53-1 (see NLM ChemIDplus info)
FDA UNII Code 731DCA35BT
ChEBI ID CHEBI:41922 (see ChEBI info)
NSC Code 3070 (see NCI DTP info)
PDQ Closed Trial Search ID 43081
PDQ Open Trial Search ID 43081 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012203

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Prostate cancer
Chemical_Formula C18H20O2
code C433
Contributing_Source FDA
Legacy_Concept_Name Diethylstilbestrol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C433

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