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Version: 17.08d (Release date: 2017-08-28)
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Ditiocarb (Code C432)

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Terms & Properties

Preferred Name: Ditiocarb

Definition: A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)

Label: Ditiocarb

NCI Thesaurus Code: C432 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012194  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Diethylcarbamodithioic Acid
Diethyldithiocarbamic Acid
Diethyldithiocarbaminic Acid

External Source Codes: 
CAS Registry Number 147-84-2 (see NLM ChemIDplus info)
FDA UNII Code 99Z2744345
PDQ Closed Trial Search ID 40247
PDQ Open Trial Search ID 40247 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012194

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H11NS2
code C432
Contributing_Source FDA
Legacy_Concept_Name Diethyldithiocarbamate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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