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Version: 17.06d (Release date: 2017-06-26)
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Zalcitabine (Code C430)

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Terms & Properties

Preferred Name: Zalcitabine

Definition: A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04)

Label: Zalcitabine

NCI Thesaurus Code: C430 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012132  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2',3'-Dideoxycytidine
ddC
Dideoxycytidine
Hivid
ZALCITABINE
Zalcitabine

External Source Codes: 
CAS Registry Number 7481-89-2 (see NLM ChemIDplus info)
FDA UNII Code 6L3XT8CB3I
ChEBI ID CHEBI:10101 (see ChEBI info)
NSC Code 606170 (see NCI DTP info)
PDQ Closed Trial Search ID 40349
PDQ Open Trial Search ID 40349 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012132

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H13N3O3
code C430
Contributing_Source FDA
Legacy_Concept_Name Zalcitabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C430

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