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Version: 17.06d (Release date: 2017-06-26)
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Diazoxide (Code C428)

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Terms & Properties

Preferred Name: Diazoxide

Definition: A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.

Label: Diazoxide

NCI Thesaurus Code: C428 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012022  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide
Diazoxide
DIAZOXIDE
Proglycem
SRG-95213

External Source Codes: 
CAS Registry Number 364-98-7 (see NLM ChemIDplus info)
FDA UNII Code O5CB12L4FN
ChEBI ID CHEBI:4495 (see ChEBI info)
NSC Code 64198 (see NCI DTP info)
NSC Code 76130 (see NCI DTP info)
PDQ Closed Trial Search ID 39290
PDQ Open Trial Search ID 39290 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012022

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant Hypertension
Chemical_Formula C8H7ClN2O2S
code C428
Contributing_Source FDA
Legacy_Concept_Name Diazoxide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C428

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