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Version: 17.06d (Release date: 2017-06-26)
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Dianhydrogalactitol (Code C425)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dianhydrogalactitol

Definition: A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04)

Label: Dianhydrogalactitol

NCI Thesaurus Code: C425 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0011967  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2,5,6 dianhydrogalactitol
1,2:5,6-dianhydrodulcitol
1,2:5,6-Dianhydrodulcitol
1,2:5,6-Diepoxydulcitol
1,2:5,6 dianhydrogalactitol
1,2:5, 6-Dianhydrogalactitol
1,2:5, 6-diepoxydulcitol
DAG
Dianhydrodulcitol
dianhydrodulcitol
Dianhydrogalactitol
diepoxydulcitol
diepoxygalactitol
Dulcitol diepoxide
dulcitol diepoxide
Galactitol
galactitol, 1,2:5,6-dianhydro- (8CI 9CI)
Galactitol, 1,2:5,6-dianhydro- (8CI 9CI)

External Source Codes: 
CAS Registry Number 23261-20-3 (see NLM ChemIDplus info)
NSC Code 132313 (see NCI DTP info)
PDQ Closed Trial Search ID 39215
PDQ Open Trial Search ID 39215 (check for NCI PDQ open clinical trial info)
UMLS CUI C0011967

Other Properties:
     Name Value (qualifiers indented underneath)
code C425
Legacy_Concept_Name Dianhydrogalactitol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C425

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