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Version: 17.06d (Release date: 2017-06-26)
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Dexamethasone (Code C422)

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Terms & Properties

Preferred Name: Dexamethasone

Definition: A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)

NCI-GLOSS Definition: A synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment.

Display Name: Dexamethasone

Label: Dexamethasone

NCI Thesaurus Code: C422 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0011777  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione
16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone
16Alpha-methyl-9alpha-fluoroprednisolone
9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
9Alpha-fluoro-16alpha-methylprednisolone
9alpha-Fluoro-16alpha- methylprednisolone
Aacidexam
Adexone
Aknichthol Dexa
Alba-Dex
Alin
Alin Depot
Alin Oftalmico
Amplidermis
Anemul mono
Auricularum
Auxiloson
Baycuten
Baycuten N
Cortidexason
Cortisumman
Decacort
Decadrol
Decadron
Decalix
Decameth
Decasone R.p.
Dectancyl
Dekacort
Deltafluorene
Deronil
Desamethasone
Desameton
Dexa-Mamallet
Dexa-Rhinosan
Dexa-Scheroson
Dexa-sine
Dexacortal
Dexacortin
Dexafarma
Dexafluorene
Dexalocal
Dexamecortin
Dexameth
Dexamethasone
DEXAMETHASONE
dexamethasone
Dexamethasonum
Dexamonozon
Dexapos
Dexinoral
Dexone
Dinormon
Fluoro-9alpha Methyl-16alpha Prednisolone
Fluorodelta
Fortecortin
Gammacorten
Hexadecadrol
Hexadrol
Lokalison-F
Loverine
Methylfluorprednisolone
Millicorten
Mymethasone
Orgadrone
Spersadex
Visumetazone

External Source Codes: 
CAS Registry Number 50-02-2 (see NLM ChemIDplus info)
FDA UNII Code 7S5I7G3JQL
ChEBI ID CHEBI:41879 (see ChEBI info)
NSC Code 34521 (see NCI DTP info)
PDQ Closed Trial Search ID 39789
PDQ Open Trial Search ID 39789 (check for NCI PDQ open clinical trial info)
UMLS CUI C0011777

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Allergic disorders; antiemetic; corneal injury; inflammatory conditions
Chemical_Formula C22H29FO5
code C422
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dexamethasone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C422

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