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Version: 17.06d (Release date: 2017-06-26)
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Danazol (Code C414)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Danazol

Definition: A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)

NCI-GLOSS Definition: A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer.

Display Name: Danazol

Label: Danazol

NCI Thesaurus Code: C414 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010961  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol
(17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol
17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole
Bonzol
Chronogyn
Cyclomen
DAN
Danazol
danazol
DANAZOL
Danocrine
Danol
Danoval
Ladogal
Win-17757
Winobanin
Win 17757

External Source Codes: 
CAS Registry Number 17230-88-5 (see NLM ChemIDplus info)
FDA UNII Code N29QWW3BUO
ChEBI ID CHEBI:4315 (see ChEBI info)
NSC Code 270916 (see NCI DTP info)
PDQ Closed Trial Search ID 39204
PDQ Open Trial Search ID 39204 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010961

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H27NO2
code C414
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Danazol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C414

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