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Version: 17.06d (Release date: 2017-06-26)
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Dactinomycin (Code C412)

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Terms & Properties

Preferred Name: Dactinomycin

Definition: A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)

NCI-GLOSS Definition: An anticancer drug that is a type of antitumor antibiotic.

Display Name: Dactinomycin

Label: Dactinomycin

NCI Thesaurus Code: C412 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010934  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
Actinomycin-[thr-val-pro-sar-meval]
Actinomycin A IV
Actinomycin C1
ACTINOMYCIN D
Actinomycin D
Actinomycin I1
Actinomycin IV
Actinomycin X 1
Cosmegen
DACT
Dactinomycin
dactinomycin
DACTINOMYCIN
Dactinomycine
Lyovac cosmegen
Lyovac Cosmegen
Meractinomycin

External Source Codes: 
CAS Registry Number 50-76-0 (see NLM ChemIDplus info)
FDA UNII Code 1CC1JFE158
ChEBI ID CHEBI:27666 (see ChEBI info)
NSC Code 3053 (see NCI DTP info)
PDQ Closed Trial Search ID 39675
PDQ Open Trial Search ID 39675 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010934

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Wilms' tumor; rhabdomyosarcoma; Ewing's sarcoma; testicular cancer; gestational trophoblastic neoplasia; choriocarcinoma; melanoma; neuroblastoma; retinoblastoma; uterine sarcomas; Kaposi's sarcoma; sarcoma botryoides; soft tissue sarcoma.
Chemical_Formula C62H86N12O16
code C412
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dactinomycin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C412

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