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Version: 17.06d (Release date: 2017-06-26)
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Dacarbazine (Code C411)

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Terms & Properties

Preferred Name: Dacarbazine

Definition: A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.

Display Name: Dacarbazine

Label: Dacarbazine

NCI Thesaurus Code: C411 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010927  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
4-(Dimethyltriazeno)imidazole-5-carboxamide
5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide
5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide
5-(dimethyltriazeno)imidazole-4-carboxamide
5-(Dimethyltriazeno)imidazole-4-carboxamide
Asercit
Biocarbazine
Dacarbazina
Dacarbazina Almirall
Dacarbazine
DACARBAZINE
dacarbazine
Dacarbazine - DTIC
Dacatic
Dakarbazin
Deticene
Detimedac
DIC
Dimethyl-triazeno-imidazole-carboximide
dimethyl-triazeno-imidazole carboxamide
Dimethyl (triazeno) imidazolecarboxamide
Dimethyl Triazeno Imidazole Carboxamide
Dimethyl Triazeno Imidazol Carboxamide
DTIC
DTIC-Dome
Fauldetic
Imidazole Carboxamide
Imidazole carboxamide
Imidazole Carboxamide Dimethyltriazeno
WR-139007

External Source Codes: 
CAS Registry Number 4342-03-4 (see NLM ChemIDplus info)
FDA UNII Code 7GR28W0FJI
ChEBI ID CHEBI:4305 (see ChEBI info)
NSC Code 45388 (see NCI DTP info)
PDQ Closed Trial Search ID 39768
PDQ Open Trial Search ID 39768 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010927

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Carcinoid cancer; Hodgkins disease; Islet cell carcinoma; Melanoma; Neuroblastoma; Soft tissue sarcoma
Chemical_Formula C6H10N6O
code C411
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dacarbazine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C411

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