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Version: 17.06d (Release date: 2017-06-26)
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Cytarabine (Code C408)

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Terms & Properties

Preferred Name: Cytarabine

Definition: An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)

NCI-GLOSS Definition: A drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite.

Display Name: Cytarabine

Label: Cytarabine

NCI Thesaurus Code: C408 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010711  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.beta.-Cytosine arabinoside
1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-.beta.-D-Arabinofuranosylcytosine
1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-Beta-D-arabinofuranosylcytosine
1.beta.-D-Arabinofuranosylcytosine
2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-
2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
Alexan
Ara-C
ARA-cell
Arabine
Arabinofuranosylcytosine
Arabinosylcytosine
Aracytidine
Aracytin
Aracytine
Beta-cytosine Arabinoside
Beta-Cytosine Arabinoside
CHX-3311
Cytarabine
cytarabine
CYTARABINE
Cytarabinum
Cytarbel
Cytosar
Cytosar-U
Cytosine-.beta.-arabinoside
Cytosine-beta-arabinoside
Cytosine Arabinoside
Erpalfa
Starasid
Tarabine PFS
U-19920
Udicil
U 19920
WR-28453

External Source Codes: 
CAS Registry Number 147-94-4 (see NLM ChemIDplus info)
FDA UNII Code 04079A1RDZ
ChEBI ID CHEBI:28680 (see ChEBI info)
NSC Code 287459 (see NCI DTP info)
PDQ Closed Trial Search ID 39015
PDQ Open Trial Search ID 39015 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010711

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute lymphocytic leukemia; Acute Nonlymphocytic leukemia; Bone marrow transplantation; Carcinomatous meningitis; Chronic myelogenous leukemia; Hogkins disease;
Accepted_Therapeutic_Use_For Meningeal leukemia; Acute Myeloid Leukemia; Meningitis lymphomatous; Myelodysplasic syndrome; Non-Hodgkins lymphoma; Ovarian cancer, intraperitoneal treatment; Retinoblastoma
Chemical_Formula C9H13N3O5
code C408
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cytosine_Arabinoside
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C408

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