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Version: 17.06d (Release date: 2017-06-26)
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Cyclosporine (Code C406)

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Terms & Properties

Preferred Name: Cyclosporine

Definition: A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)

NCI-GLOSS Definition: A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.

Display Name: Cyclosporine

Label: Cyclosporine

NCI Thesaurus Code: C406 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010592  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
27-400
Ciclosporin
CsA
Cyclosporin
Cyclosporine
cyclosporine
CYCLOSPORINE
Cyclosporin A
Gengraf
Neoral
OL 27-400
Sandimmun
Sandimmune
SangCya

External Source Codes: 
CAS Registry Number 59865-13-3 (see NLM ChemIDplus info)
FDA UNII Code 83HN0GTJ6D
ChEBI ID CHEBI:4031 (see ChEBI info)
NSC Code 290193 (see NCI DTP info)
PDQ Closed Trial Search ID 39201
PDQ Open Trial Search ID 39201 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010592

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Allogenic transplants; prophylaxis of organ rejection in bone marrow; kidney; liver and heart transplants; psoriasis; rheumatoid arthritis; various diseases that involve autoimmune response
Chemical_Formula C62H111N11O12
code C406
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cyclosporine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C406

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