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Version: 17.06d (Release date: 2017-06-26)
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Cyclophosphamide (Code C405)

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Terms & Properties

Preferred Name: Cyclophosphamide

Definition: A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

NCI-GLOSS Definition: A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.

Display Name: Cyclophosphamide

Label: Cyclophosphamide

NCI Thesaurus Code: C405 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010583  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Cyclophosphamide
1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate
2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate
2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate
2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
Carloxan
Ciclofosfamida
Ciclofosfamide
Cicloxal
Clafen
Claphene
CP monohydrate
CTX
CYCLO-cell
Cycloblastin
Cycloblastine
Cyclophospham
Cyclophosphamide
cyclophosphamide
CYCLOPHOSPHAMIDE
Cyclophosphamidum
Cyclophosphamid monohydrate
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclostin
Cyclostine
Cytophosphan
Cytophosphane
Cytoxan
Fosfaseron
Genoxal
Genuxal
Ledoxina
Mitoxan
N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate
N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate
N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate
N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate
Neosar
Revimmune
Syklofosfamid
WR- 138719

External Source Codes: 
CAS Registry Number 6055-19-2 (see NLM ChemIDplus info)
FDA UNII Code 8N3DW7272P
ChEBI ID CHEBI:4026 (see ChEBI info)
NSC Code 26271 (see NCI DTP info)
PDQ Closed Trial Search ID 39748
PDQ Open Trial Search ID 39748 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010583

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Leukemias; Lupus nephritis; Lymphoma; Multiple myeloma; Neuroblastoma; Nephrotic syndrome; Ovarian cancer; Retinoblastoma; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia
Chemical_Formula C7H15Cl2N2O2P.H2O
code C405
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cyclophosphamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C405

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