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Version: 17.06d (Release date: 2017-06-26)
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Diltiazem Hydrochloride (Code C398)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Diltiazem Hydrochloride

Definition: A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)

Label: Diltiazem Hydrochloride

NCI Thesaurus Code: C398 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010285  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cardizem
Diltiazem HCl
Diltiazem Hydrochloride
DILTIAZEM HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 33286-22-5 (see NLM ChemIDplus info)
FDA UNII Code OLH94387TE
ChEBI ID CHEBI:645509 (see ChEBI info)
PDQ Closed Trial Search ID 40122
PDQ Open Trial Search ID 40122 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010285

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H26N2O4S.HCl
code C398
Contributing_Source FDA
Legacy_Concept_Name Diltiazem_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C398

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