skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Alteplase (Code C39607)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Alteplase

Definition: A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

NCI-GLOSS Definition: A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.

Label: Alteplase

NCI Thesaurus Code: C39607 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0032143  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Plasminogen Activator (Human Tissue-Type Protein Moiety)
Recombinant Tissue Plasminogen Activator
recombinant tissue plasminogen activator

External Source Codes: 
CAS Registry Number 105857-23-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42033
PDQ Open Trial Search ID 42033 (check for NCI PDQ open clinical trial info)
UMLS CUI C0032143

Other Properties:
     Name Value (qualifiers indented underneath)
code C39607
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Tissue_Plasminogen_Activator
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom