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Version: 17.06d (Release date: 2017-06-26)
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Alteplase (Code C39607)

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Terms & Properties

Preferred Name: Alteplase

Definition: A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

NCI-GLOSS Definition: A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.

Label: Alteplase

NCI Thesaurus Code: C39607 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0032143  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Activase
ALTEPLASE
Alteplase
Plasminogen Activator (Human Tissue-Type Protein Moiety)
r-tPA
Recombinant Tissue Plasminogen Activator
recombinant tissue plasminogen activator
rt-PA

External Source Codes: 
CAS Registry Number 105857-23-6 (see NLM ChemIDplus info)
FDA UNII Code 1RXS4UE564
PDQ Closed Trial Search ID 42033
PDQ Open Trial Search ID 42033 (check for NCI PDQ open clinical trial info)
UMLS CUI C0032143

Other Properties:
     Name Value (qualifiers indented underneath)
code C39607
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Tissue_Plasminogen_Activator
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C39607

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