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Version: 17.06d (Release date: 2017-06-26)
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Valerian (Code C38725)

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Terms & Properties

Preferred Name: Valerian

Definition: An herbal extract isolated from the root of the plant Valeriana officinalis with sedative and anxiolytic activities. Valeriana officinalis extract contains four distinct classes of phytochemical constituents: volatile oils; sesquiterpenoids, including valerenic acid and its hydroxyl and acetoxyl derivative; valepotriates; and volatile pyridine alkaloids. Although the exact mechanism of action has not been established, the sesquiterpenoids in Valeriana officinalis extract, particularly valerenic acid, appear to account for its sedative and anxiolytic effects. Valerenic acid is both a subtype-selective GABA-A receptor agonist and a 5HT-5A receptor partial agonist. The sedative-hypnotic benzodiazepines are GABA-A receptor agonists.

Display Name: Valerian

Label: Valerian

NCI Thesaurus Code: C38725 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0795675  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Valerian
VALERIAN
Valeriana Officinalis Extract

External Source Codes: 
FDA UNII Code JWF5YAW3QW
PDQ Closed Trial Search ID 350071
PDQ Open Trial Search ID 350071 (check for NCI PDQ open clinical trial info)
UMLS CUI C0795675

Other Properties:
     Name Value (qualifiers indented underneath)
code C38725
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valeriana_Officinalis_Extract
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38725

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