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Version: 17.06d (Release date: 2017-06-26)
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Axitinib (Code C38718)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Axitinib

Definition: An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein tyrosine kinase inhibitors.

Display Name: Axitinib

Label: Axitinib

NCI Thesaurus Code: C38718 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1700874  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AG-013736
AG013736
Axitinib
axitinib
AXITINIB
Inlyta
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide

External Source Codes: 
CAS Registry Number 319460-85-0 (see NLM ChemIDplus info)
FDA UNII Code C9LVQ0YUXG
PDQ Closed Trial Search ID 352181
PDQ Open Trial Search ID 352181 (check for NCI PDQ open clinical trial info)
UMLS CUI C1700874

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H18N4OS
code C38718
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name AG-013736
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38718

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