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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Anakinra (Code C38717)

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Terms & Properties

Preferred Name: Anakinra

Definition: A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)

NCI-GLOSS Definition: A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist.

Display Name: Anakinra

Label: Anakinra

NCI Thesaurus Code: C38717 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0245109  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 143090-92-0 (see NLM ChemIDplus info)
FDA UNII Code 9013DUQ28K
PDQ Closed Trial Search ID 43007
PDQ Open Trial Search ID 43007 (check for NCI PDQ open clinical trial info)
UMLS CUI C0245109

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Rheumatoid arthritis
code C38717
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anakinra
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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