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Version: 17.06d (Release date: 2017-06-26)
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Lorvotuzumab Mertansine (Code C38714)

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Terms & Properties

Preferred Name: Lorvotuzumab Mertansine

Definition: An immunoconjugate of a humanized murine monoclonal antibody (huN-901) and DMI, a semi-synthetic derivative of the plant-derived ansa macrolide maytansine. The antibody moiety of BB-10901 selectively attaches to CD56 antigen, a neural cell adhesion molecule (NCAM)) expressed on the surface of cells of small cell lung cancer (SCLC) and other neuroendocrine (NE) tumors. Thus, the DMI conjugate is targeted specifically to CD56-expressing tumor cells, where it inhibits tubulin polymerization and assembly, resulting in inhibition of mitosis and cell cycle arrest in the S phase. (NCI04)

NCI-GLOSS Definition: A substance that combines a monoclonal antibody (huN901) with an anticancer drug (DM1), and is being studied in the treatment of certain cancers, including non-small cell lung cancer. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

Display Name: Lorvotuzumab Mertansine

Label: Lorvotuzumab Mertansine

NCI Thesaurus Code: C38714 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987530  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Human NCAM-1 Monoclonal Antibody N901
BB-10901
huN901-DM1
IMGN901
Lorvotuzumab Mertansine
LORVOTUZUMAB MERTANSINE

External Source Codes: 
CAS Registry Number 1008106-64-6 (see NLM ChemIDplus info)
FDA UNII Code 0IVD6ASY0W
PDQ Closed Trial Search ID 346110
PDQ Open Trial Search ID 346110 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987530

Other Properties:
     Name Value (qualifiers indented underneath)
code C38714
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BB-10901
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38714

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