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Version: 16.10e (Release date: 2016-10-31)
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Dasatinib (Code C38713)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dasatinib

Definition: An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.

NCI-GLOSS Definition: A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. BMS-354825 is also being studied in the treatment of certain other blood diseases and types of cancer. BMS-354825 binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor.

Display Name: Dasatinib

Label: Dasatinib

NCI Thesaurus Code: C38713 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1455147  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-354825
Dasatinib
DASATINIB
dasatinib
Sprycel

External Source Codes: 
CAS Registry Number 863127-77-9 (see NLM ChemIDplus info)
FDA UNII Code RBZ1571X5H
NSC Code 732517 (see NCI DTP info)
PDQ Closed Trial Search ID 315885
PDQ Open Trial Search ID 315885 (check for NCI PDQ open clinical trial info)
UMLS CUI C1455147

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic myeloid leukemia; Philadelphia chromosome-positive acute lymphoblastic leukemia
Chemical_Formula C22H26ClN7O2S.H2O
code C38713
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BMS-354825
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38713

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