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Version: 16.11d (Release date: 2016-11-28)
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Deslorelin (Code C38709)

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Terms & Properties

Preferred Name: Deslorelin

Definition: A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It is a type of gonadotropin-releasing hormone analog.

Display Name: Deslorelin

Label: Deslorelin

NCI Thesaurus Code: C38709 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0083220  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Swine)
Deslorelin
DESLORELIN
deslorelin
Ovuplant

External Source Codes: 
CAS Registry Number 57773-65-6 (see NLM ChemIDplus info)
FDA UNII Code TKG3I66TVE
PDQ Closed Trial Search ID 357620
PDQ Open Trial Search ID 357620 (check for NCI PDQ open clinical trial info)
UMLS CUI C0083220

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Central precocious puberty
Chemical_Formula C64H83N17O12
code C38709
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Deslorelin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38709

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