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Version: 17.06d (Release date: 2017-06-26)
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Lamotrigine (Code C38703)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lamotrigine

Definition: A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

NCI-GLOSS Definition: A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants.

Label: Lamotrigine

NCI Thesaurus Code: C38703 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0678180  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lamictal
lamotrigine
Lamotrigine
LAMOTRIGINE

External Source Codes: 
CAS Registry Number 84057-84-1 (see NLM ChemIDplus info)
FDA UNII Code U3H27498KS
ChEBI ID CHEBI:6367 (see ChEBI info)
PDQ Closed Trial Search ID 328241
PDQ Open Trial Search ID 328241 (check for NCI PDQ open clinical trial info)
UMLS CUI C0678180

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Epilepsy
Chemical_Formula C9H7Cl2N5
code C38703
Contributing_Source FDA
DesignNote Clinical Trial--Chemotherapy-induced neuropathy
Legacy_Concept_Name Lamotrigine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38703

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