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Version: 17.06d (Release date: 2017-06-26)
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OSI-7904L (Code C38694)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: OSI-7904L

Definition: A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.

Label: OSI-7904L

NCI Thesaurus Code: C38694 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328144  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GS7904L
OSI-7904L

External Source Codes: 
PDQ Closed Trial Search ID 352016
PDQ Open Trial Search ID 352016 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328144

Other Properties:
     Name Value (qualifiers indented underneath)
code C38694
Legacy_Concept_Name OSI-7904L
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38694

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