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Version: 17.06d (Release date: 2017-06-26)
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Paricalcitol (Code C38693)

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Terms & Properties

Preferred Name: Paricalcitol

Definition: A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)

NCI-GLOSS Definition: A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs.

Display Name: Paricalcitol

Label: Paricalcitol

NCI Thesaurus Code: C38693 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0724464  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(7e,22e)-19-Nor-9,10-Secoergosta-5,7,22-Triene-1Alpha,3Beta,25-Triol
Compound 49510
Paricalcitol
PARICALCITOL
paricalcitol
Zemplar

External Source Codes: 
CAS Registry Number 131918-61-1 (see NLM ChemIDplus info)
FDA UNII Code 6702D36OG5
ChEBI ID CHEBI:7931 (see ChEBI info)
PDQ Closed Trial Search ID 315740
PDQ Open Trial Search ID 315740 (check for NCI PDQ open clinical trial info)
UMLS CUI C0724464

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Secondary hyperparathyroidism, prevention and treatment
Chemical_Formula C27H44O3
code C38693
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Paricalcitol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38693

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