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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Pertuzumab (Code C38692)

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Terms & Properties

Preferred Name: Pertuzumab

Definition: A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)

NCI-GLOSS Definition: A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.

Display Name: Pertuzumab

Label: Pertuzumab

NCI Thesaurus Code: C38692 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328025  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2C4 Antibody
Immunoglobulin G1, Anti-(Human V (Receptor)) (Human-Mouse Monoclonal 2C4 Heavy Chain), Disulfide with Human-Mouse Monoclonal 2C4 Kappa-Chain, Dimer
MoAb 2C4
Monoclonal Antibody 2C4

External Source Codes: 
CAS Registry Number 380610-27-5 (see NLM ChemIDplus info)
NSC Code 740102 (see NCI DTP info)
PDQ Closed Trial Search ID 322808
PDQ Open Trial Search ID 322808 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328025

Other Properties:
     Name Value (qualifiers indented underneath)
code C38692
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pertuzumab
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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