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Version: 17.06d (Release date: 2017-06-26)
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Phentolamine Mesylate (Code C38691)

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Terms & Properties

Preferred Name: Phentolamine Mesylate

Definition: The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.

Display Name: Phentolamine Mesylate

Label: Phentolamine Mesylate

NCI Thesaurus Code: C38691 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0733398  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Monomethanesulfonate
Phentolamine Mesylate

External Source Codes: 
CAS Registry Number 65-28-1 (see NLM ChemIDplus info)
FDA UNII Code Y7543E5K9T
PDQ Closed Trial Search ID 360460
PDQ Open Trial Search ID 360460 (check for NCI PDQ open clinical trial info)
UMLS CUI C0733398

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Dermal necrosis; Hypertensive-associated episodes with pheochromocytoma, prevention or control
Chemical_Formula C17H19N3O.CH4O3S
code C38691
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Phentolamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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