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Version: 17.06d (Release date: 2017-06-26)
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Phosphomannopentaose Sulfate (Code C38690)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Phosphomannopentaose Sulfate

Definition: A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Phosphomannopentaose sulfate inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antiangiogenesis agents.

Display Name: Phosphomannopentaose Sulfate

Label: Phosphomannopentaose Sulfate

NCI Thesaurus Code: C38690 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0769628  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Phosphomannopentaose Sulfate
PI-88

External Source Codes: 
PDQ Closed Trial Search ID 339562
PDQ Open Trial Search ID 339562 (check for NCI PDQ open clinical trial info)
UMLS CUI C0769628

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant melanoma
code C38690
Contributing_Source CTRP
Legacy_Concept_Name PI-88
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38690

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