|Phosphomannopentaose Sulfate (Code C38690)|
|Terms & Properties|
Preferred Name: Phosphomannopentaose Sulfate
Definition: A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Phosphomannopentaose sulfate inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis.
NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antiangiogenesis agents.
Display Name: Phosphomannopentaose Sulfate
Label: Phosphomannopentaose Sulfate
NCI Metathesaurus Link: C0769628 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||339562|
|PDQ Open Trial Search ID||339562 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|