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Version: 17.08d (Release date: 2017-08-28)
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Defined Green Tea Catechin Extract (Code C38689)

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Terms & Properties

Preferred Name: Defined Green Tea Catechin Extract

Definition: A proprietary formulation composed of a defined, decaffeinated green tea extract, containing polyphenolic flavonol catechins, isolated from the plant Camellia sinensis with antiviral, antioxidant, and potential chemopreventive activities. The primary catechins found in green tea are epicatechin (EC), epigallocatechin (EGC), epicatechin-3 gallate (ECG), and epigallocatechin-3-gallate (EGCG), the most potent. As potential chemopreventive agents, catechins scavenge free radicals; inhibit enzymes involved in cell replication and DNA synthesis; interfere with cell-to-cell contact adhesion; and inhibit various intracellular communication pathways required for cell division. In addition, it has been postulated that EGCG may trap growth factors such platelet-derived growth factor (PDGF) on cell membranes, immobilizing growth factors on cell membranes and preventing ligand-receptor crosslinking and growth factor receptor activation.

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. It is made from decaffeinated green tea, and contains chemicals called catechins, which are antioxidants.

Display Name: Defined Green Tea Catechin Extract

Label: Defined Green Tea Catechin Extract

NCI Thesaurus Code: C38689 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0917976  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Defined Green Tea Catechin Extract
Polyphenon E
Polyphenon E TM

External Source Codes: 
PDQ Closed Trial Search ID 506041
PDQ Open Trial Search ID 506041 (check for NCI PDQ open clinical trial info)
UMLS CUI C0917976

Other Properties:
     Name Value (qualifiers indented underneath)
code C38689
Contributing_Source CTRP
Legacy_Concept_Name Polyphenon_E
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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