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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Siplizumab (Code C38685)

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Terms & Properties

Preferred Name: Siplizumab

Definition: A humanized monoclonal immunoglobulin G1 antibody with potential antineoplastic activity. Siplizumab binds to CD2, a specific receptor found in T cells and NK cells, thereby triggering a host immune response that results in lysis of CD2+ cells, selective suppression of the immune system, and control of activated T cell growth.

NCI-GLOSS Definition: A monoclonal antibody that is being studied in the treatment of certain lymphoproliferative disorders and psoriasis.

Label: Siplizumab

NCI Thesaurus Code: C38685 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328709  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 346499
PDQ Open Trial Search ID 346499 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328709

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For T-cell lymphoma
code C38685
Legacy_Concept_Name Siplizumab
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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