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Version: 17.06d (Release date: 2017-06-26)
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Ispinesib (Code C38131)

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Terms & Properties

Preferred Name: Ispinesib

Definition: A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Ispinesib blocks a protein that tumor cells need to divide. It is a type of mitotic inhibitor.

Display Name: Ispinesib

Label: Ispinesib

NCI Thesaurus Code: C38131 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527260  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CK0238273
Ispinesib
ISPINESIB
ispinesib
SB-715992

External Source Codes: 
CAS Registry Number 336113-53-2 (see NLM ChemIDplus info)
FDA UNII Code BKT5F9C2NI
NSC Code 727990 (see NCI DTP info)
PDQ Closed Trial Search ID 391236
PDQ Open Trial Search ID 391236 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527260

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H33ClN4O2
code C38131
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name SB-715992
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38131

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