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Version: 17.06d (Release date: 2017-06-26)
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Betulinic Acid (Code C38126)

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Terms & Properties

Preferred Name: Betulinic Acid

Definition: A pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells.

Display Name: Betulinic Acid

Label: Betulinic Acid

NCI Thesaurus Code: C38126 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0053530  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid
ALS-357
Betulinic Acid
BETULINIC ACID
Mairin

External Source Codes: 
CAS Registry Number 472-15-1 (see NLM ChemIDplus info)
FDA UNII Code 4G6A18707N
NSC Code 113090 (see NCI DTP info)
PDQ Closed Trial Search ID 496932
PDQ Open Trial Search ID 496932 (check for NCI PDQ open clinical trial info)
UMLS CUI C0053530

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H48O3
code C38126
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Betulinic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38126

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