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Version: 17.06d (Release date: 2017-06-26)
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Clotrimazole (Code C381)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Clotrimazole

Definition: A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.

Label: Clotrimazole

NCI Thesaurus Code: C381 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0009074  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
CLOT
Clotrimazole
CLOTRIMAZOLE
Gyne-Lotrimin
Lotrimin
Mycelex
Mycelex Troche

External Source Codes: 
CAS Registry Number 23593-75-1 (see NLM ChemIDplus info)
FDA UNII Code G07GZ97H65
ChEBI ID CHEBI:3764 (see ChEBI info)
NSC Code 257473 (see NCI DTP info)
PDQ Closed Trial Search ID 39116
PDQ Open Trial Search ID 39116 (check for NCI PDQ open clinical trial info)
UMLS CUI C0009074

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H17ClN2
code C381
Contributing_Source FDA
Legacy_Concept_Name Clotrimazole
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C381

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