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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Clomiphene Citrate (Code C379)

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Terms & Properties

Preferred Name: Clomiphene Citrate

Definition: The citrate salt form of clomiphene, a triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)

Label: Clomiphene Citrate

NCI Thesaurus Code: C379 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0546859  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine Citrate
2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine Citrate (1:1)
Clomiphene Citrate

External Source Codes: 
CAS Registry Number 50-41-9 (see NLM ChemIDplus info)
FDA UNII Code 1B8447E7YI
ChEBI ID CHEBI:3753 (see ChEBI info)
NSC Code 35770 (see NCI DTP info)
PDQ Closed Trial Search ID 39542
PDQ Open Trial Search ID 39542 (check for NCI PDQ open clinical trial info)
UMLS CUI C0546859

Other Properties:
     Name Value (qualifiers indented underneath)
code C379
Contributing_Source FDA
Legacy_Concept_Name Clomiphene
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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