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Version: 17.06d (Release date: 2017-06-26)
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Tanespimycin (Code C37899)

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Terms & Properties

Preferred Name: Tanespimycin

Definition: A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is made from an antibiotic called geldanamycin. Tanespimycin helps cause the breakdown of certain proteins in the cell, and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of HSP90 inhibitor.

Display Name: Tanespimycin

Label: Tanespimycin

NCI Thesaurus Code: C37899 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0675974  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17-(Allylamino)-17-demethoxygeldanamycin
17-AAG
17-Allylamino-17-demethoxygeldanamycin
17-Demethoxy-17-(2-propenylamino)geldanamycin
17-N-allylamino-17-demethoxygeldanamycin
17-N-allylamino-17-demethoxy geldanamycin
Geldanamycin, 17-allylamino-17-demethoxy-
KOS-953
Tanespimycin
TANESPIMYCIN
tanespimycin

External Source Codes: 
CAS Registry Number 75747-14-7 (see NLM ChemIDplus info)
FDA UNII Code 4GY0AVT3L4
ChEBI ID CHEBI:64153 (see ChEBI info)
NSC Code 330507 (see NCI DTP info)
PDQ Closed Trial Search ID 43635
PDQ Open Trial Search ID 43635 (check for NCI PDQ open clinical trial info)
UMLS CUI C0675974

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Myelogenous Leukemia
Chemical_Formula C31H43N3O8
code C37899
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _17-Allylamino_17-demethoxygeldanamycin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37899

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