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Version: 17.06d (Release date: 2017-06-26)
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Cisplatin (Code C376)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cisplatin

Definition: An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.

NCI-GLOSS Definition: A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent.

Display Name: Cisplatin

Label: Cisplatin

NCI Thesaurus Code: C376 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008838  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(SP-4-2)-Diamminedichloroplatinum
Abiplatin
Blastolem
Briplatin
CDDP
Cis-diammine-dichloroplatinum
Cis-diamminedichloridoplatinum
Cis-diamminedichloroplatinum
Cis-diamminedichloro Platinum (II)
Cis-dichloroammine Platinum (II)
Cis-platinous Diamine Dichloride
Cis-platinum
Cis-platinum II
Cis-platinum II Diamine Dichloride
Cismaplat
Cisplatin
cisplatin
CISPLATIN
Cisplatina
Cisplatinum
Cisplatyl
Citoplatino
Citosin
Cysplatyna
DDP
Lederplatin
Metaplatin
Neoplatin
Peyrone's Chloride
Peyrone's Salt
Placis
Plastistil
Platamine
Platiblastin
Platiblastin-S
Platinex
Platinol
Platinol-AQ
Platinol-AQ VHA Plus
Platinol- AQ
Platinoxan
Platinum
Platinum, Diaminedichloro-, cis- (8CI)
Platinum Diamminodichloride
Platiran
Platistin
Platosin

External Source Codes: 
CAS Registry Number 15663-27-1 (see NLM ChemIDplus info)
FDA UNII Code Q20Q21Q62J
ChEBI ID CHEBI:27899 (see ChEBI info)
NSC Code 119875 (see NCI DTP info)
PDQ Closed Trial Search ID 39515
PDQ Open Trial Search ID 39515 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008838

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic testicular cancer; ovarian cancer; head and neck cancer; breast cancer; Hodgkin's and non-Hodgkin's lymphoma; myeloma and melanoma
Chemical_Formula 2Cl.Pt.2H3N
code C376
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cisplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C376

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