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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus-mediated Human Interleukin-12 (Code C37515)

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Terms & Properties

Preferred Name: Adenovirus-mediated Human Interleukin-12

Definition: A replication incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12 (IL-12) (Ad.hIL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, the adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

Label: Adenovirus-mediated Human Interleukin-12

NCI Thesaurus Code: C37515 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831638  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenovirus-mediated Human Interleukin-12

External Source Codes: 
PDQ Closed Trial Search ID 436005
PDQ Open Trial Search ID 436005 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831638

Other Properties:
     Name Value (qualifiers indented underneath)
code C37515
Legacy_Concept_Name Adenovirus_Interleukin-12-Gene
Semantic_Type Therapeutic or Preventive Procedure

Additional Concept Data: 
Defined Fully by Roles: No  


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