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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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Cenersen (Code C37454)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cenersen

Definition: A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics.

Display Name: Cenersen

Label: Cenersen

NCI Thesaurus Code: C37454 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700610  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aezea
Cenersen
EL625
OL(1)p53

External Source Codes: 
PDQ Closed Trial Search ID 354249
PDQ Open Trial Search ID 354249 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700610

Other Properties:
Name Value (qualifiers indented underneath)
code C37454
Contributing_Source CTRP
Legacy_Concept_Name EL625
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37454

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