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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Efaproxiral (Code C37453)

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Terms & Properties

Concept Status: Retired Concept  (See:  Efaproxiral )

Preferred Name: Efaproxiral

Definition: A synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. (NCI04)

Label: Efaproxiral

NCI Thesaurus Code: C37453 (Search for linked caDSR metadata)  (search value sets)

Synonyms & Abbreviations: (see Synonym Details)

External Source CodesNone

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Radiosensitizer, adjuvant to whole brain radiation therapy
code C37453
Concept_Status Retired_Concept
deprecated true
DesignNote Merged with RSR-13
OLD_KIND Chemicals_and_Drugs_Kind
OLD_PARENT Radiosensitizing_Agent
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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