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Version: 17.06d (Release date: 2017-06-26)
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Ixabepilone (Code C37452)

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Terms & Properties

Preferred Name: Ixabepilone

Definition: An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.

NCI-GLOSS Definition: A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.

Display Name: Ixabepilone

Label: Ixabepilone

NCI Thesaurus Code: C37452 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1135132  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Azaepothilone B
BMS 247550
Epothilone-B BMS 247550

External Source Codes: 
CAS Registry Number 219989-84-1 (see NLM ChemIDplus info)
FDA UNII Code K27005NP0A
ChEBI ID CHEBI:63605 (see ChEBI info)
NSC Code 710428 (see NCI DTP info)
PDQ Closed Trial Search ID 37860
PDQ Open Trial Search ID 37860 (check for NCI PDQ open clinical trial info)
UMLS CUI C1135132

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic or locally advanced breast cancer.
Chemical_Formula C27H42N2O5S
code C37452
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ixabepilone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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